The aim of this study is to prove the effect of Living Silica on the supramolecular restructuring of the extra-cellular matrix in the skin ageing process of hairless mice by evaluating the influence of Living Silica on the evaluation of the structural organization of the dermis. For this, the young untreated skin of 6-month-old mice (testing batch) is compared with that of two batches of 17-month-old mice, one of which is treated and the other is untreated. The treated mice received a daily external application of Living Silica Gel, 5 days a week for 5 months at the age of 12 months. The findings showed that the collagen and elastin fibres were restructured, the interfibrillar spaces were maintained and the thickness of the dermis was maintained. A structural organization of the dermis similar to those of 6 months old was observed.